The Chicago Cubs and San Diego Padres will face-off for the second time in as many days on Saturday night.

The Cubs squeaked by the Padres in the opening game of the series, winning by a final score of 2-1. They'll roll with Drew Smyly (3.45 ERA) in Game 2. He'll face-off against Yu Darvish (4.61 ERA) of the Padres.

Let's take a look at the odds for the game and then I'll give you my best bet.

Cubs vs. Padres odds, run line, and total

Cubs vs. Padres prediction and pick

Drew Smyly could be in for a rough night tonight as he has to take on a Padres team that's significantly better against left-handed pitchers. The Padres OPS increases from .672 against right-handed pitchers to .740 against lefties.

Smyly has faced the Padres once already this season, giving up four hits and two earned runs in only 5.0 innings in a game that the Cubs ended up losing by a final score of 5-3.

The Cubs offense has gone ice cold lately, ranking 29th in OPS over the past 14 days.

There's no reason why the Padres can't pounce on this Chicago club and get the win as home favorites.

–

Game odds refresh periodically and are subject to change.