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One of the scientists whose work pioneered the development of medications such as Ozempic and Wegovy has revealed why life may become “so miserably boring” after two years of using the drug. Ozempic is an FDA-approved medication used for the treatment of type 2 diabetes. It works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), which regulates blood sugar levels and slows down the rate at which food leaves the stomach, often creating the feeling of fullness. These semaglutide injections – sold under the brand names Ozempic and Wegovy – have soared in popularity as many people, including Hollywood celebrities, have used it for weight loss. What’s more, people have also found Ozempic has been effective in curing their addictive habits, like drinking, smoking, shopping, or nail biting. However, because of Ozempic’s increasing popularity, it has led to national shortages of the type 2 diabetes treatment – leaving those who actually need it without. In an interview with Wired, professor Jens Juul Holst – who received the Warren Alpert Foundation Prize in 2021 for his work developing treatments based on the GLP-1 hormone – spoke about the effects of Ozempic, and why he believes many people will stop taking the medication after just a few years. “What happens is that you lose your appetite and also the pleasure of eating, and so I think there’s a price to be paid when you do that,” Holst told Wired. “If you like food, then that pleasure is gone. The craving for food for some people is taken away when they take GLP-1 drugs.” He continued: “That may eventually be a problem, that once you’ve been on this for a year or two, life is so miserably boring that you can’t stand it any longer and you have to go back to your old life.” Holst added that medications like Ozempic and Wegovy have been on the market since 2005, though studies show that these people don’t stay on them for very long. “It’s just like every other drug, they don’t stay on it for many reasons,” he explained. “One of the reasons, as I said, is that once you have tried it and you realise you’ve lost interest in food, then that may be enough.” “We don’t know why people stop taking these drugs, but we know for a fact that they do stop. They do that all over the world.” A 2020 study found that 70 per cent of people who took GLP-1 drugs for type 2 diabetes stopped taking them within two years. However, this could pose a problem for many patients taking semaglutide injections. Research has found that people who stopped taking Ozempic or Wegovy for weight loss experienced weight rebound. A trial published in April 2022 saw participants gain back two thirds of the weight they had lost after 68 weeks of taking semaglutide. As for celebrities who use the once-weekly injection for weight loss, despite not having diabetes or clinical obesity, Hans instead called attention to the “many terrible problems” that those with diabetes have struggled with by not having drugs like Ozempic readily available. “Have you ever visited a diabetes hospital? It’s really deplorable,” he said. “People come in with amputated limbs and compromised cognitive functions and heart problems or they can barely move – they’re miserable and depressed. It’s really serious. There is so much you can improve with a drug that is not only a weight-loss drug but is also an anti-diabetic.” Amidst the popularity of semaglutide injections, the US Food and Drug Administration has issued warnings for consumers not to use off-brand versions of Ozempic or Wegovy, because they may not include the same GLP-1 hormone used in approved medications. Earlier this month, agency officials reported problems with patients using compounded versions of semaglutide – which combines traditional semaglutide with other ingredients. These drugs are not FDA-approved, and the agency does not verify the safety or effectiveness of compounded drugs. Consumers should only use drugs containing semaglutide with a prescription from a licensed health care provider and obtained from a state-licensed pharmacy or other facilities registered with the FDA, the agency said. Read More What is ‘Ozempic face’? Doctors warn about facial ageing side effect of diabetes medications How does Wegovy work? The ‘game changing’ weight loss drug beloved by Hollywood FDA warns against using off-brand versions of Ozempic, Wegovy for weight loss Pregnant Stassi Schroeder admits she wants to ‘try’ Ozempic after giving birth Doctors warn about ‘Ozempic face’ side effect of medications Amy Schumer says she stopped taking Ozempic because of side-effects

Does very hot weather leave you feeling more exhausted and lethargic than usual? There might be an initial surge of joy when the sun finally comes out – but once temperatures really creep up, we can end up feeling physically drained, wondering whether we should follow the Mediterranean’s lead and start introducing daily siestas. So, why does hot weather make us so tired? We asked a doctor to explain… Our bodies have to work harder in the heat “When the weather is hot, our bodies have to work harder to cool themselves down,” says Dr Zulqarnain Shah, medical director at SSP Health and GP at SSP Health practice Colne Road Surgery. “The body’s natural cooling mechanism involves increasing blood circulation near the skin’s surface and promoting sweat production. These physiological changes can lead to fatigue and a feeling of lethargy. It is essential to recognise that this fatigue is a normal response to heat and is typically temporary.” Dehydration Low energy and tiredness are also common when you’re lacking hydration. “Hot weather increases the rate of fluid loss through sweating, leading to dehydration. Dehydration can contribute to fatigue and make you feel even more lethargic,” adds Dr Shah. “To avoid this, it’s important to stay adequately hydrated by drinking plenty of fluids, especially water. Aim to drink even when you’re not feeling thirsty, as thirst is not always an accurate indicator of dehydration.” Heat exhaustion “Prolonged exposure to heat can result in heat exhaustion, a condition characterised by symptoms such as heavy sweating, weakness, dizziness, nausea, headache, and muscle cramps. If you experience these warning signs, it’s crucial to move to a cooler environment, drink fluids, and rest. If symptoms persist or worsen, seek medical attention promptly,” says Shah. It’s important to pay attention to warning signs, as if heat stroke develops, this is a medical emergency. Shah stresses: “Heat stroke is a severe and potentially life-threatening condition that requires immediate medical intervention. It occurs when the body’s temperature regulation fails, and the core temperature rises dangerously high. “Symptoms may include a high body temperature (above 39.4C), altered mental state, confusion, rapid breathing, rapid heartbeat, and even loss of consciousness. If you suspect heat stroke, call emergency services immediately.” Sleep deprivation The extra tiredness could also be linked to poor sleep, as this can really suffer in the heat. “Hot temperatures can disrupt sleep and lead to poor sleep quality. The body needs to cool down to initiate sleep, and the excessive heat can make it difficult to reach the optimal sleep temperature,” explains Shah. “To improve sleep in hot weather, consider using fans or air conditioning, wearing lightweight and breathable sleepwear, keeping your bedroom well-ventilated, and using lighter bedding.” Pre-existing conditions could get worse Many people living with chronic or long-term health conditions deal with fatigue, which may flare up during heatwaves. “Hot weather can exacerbate symptoms and increase fatigue in individuals with certain chronic health conditions. Conditions such as heart disease, kidney problems, and respiratory issues can be particularly sensitive to heat,” notes Shah. “It’s vital to be aware of your specific health condition and consult with your healthcare provider for personalised advice on managing your symptoms during hot weather. They may recommend staying in cooler environments, adjusting medications, or monitoring your fluid intake more closely.” Read More Airbnb customer furious after being charged extra over dog hair People seek hay fever advice once every three seconds, says NHS England Why is my hay fever so bad at the moment?

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Does very hot weather leave you feeling more exhausted and lethargic than usual? There might be an initial surge of joy when the sun finally comes out – but once temperatures really creep up, we can end up feeling physically drained, wondering whether we should follow the Mediterranean’s lead and start introducing daily siestas. So, why does hot weather make us so tired? We asked a doctor to explain… Bodies have to work harder in the heat“When the weather is hot, our bodies have to work harder to cool themselves down,” says Dr Zulqarnain Shah, medical director at SSP Health and GP at SSP Health practice Colne Road Surgery. “The body’s natural cooling mechanism involves increasing blood circulation near the skin’s surface and promoting sweat production. These physiological changes can lead to fatigue and a feeling of lethargy. It is essential to recognise that this fatigue is a normal response to heat and is typically temporary.” Dehydration Low energy and tiredness are also common when you’re lacking hydration. “Hot weather increases the rate of fluid loss through sweating, leading to dehydration. Dehydration can contribute to fatigue and make you feel even more lethargic,” adds Dr Shah. “To avoid this, it’s important to stay adequately hydrated by drinking plenty of fluids, especially water. Aim to drink even when you’re not feeling thirsty, as thirst is not always an accurate indicator of dehydration.” Heat exhaustion “Prolonged exposure to heat can result in heat exhaustion, a condition characterised by symptoms such as heavy sweating, weakness, dizziness, nausea, headache, and muscle cramps. If you experience these warning signs, it’s crucial to move to a cooler environment, drink fluids, and rest. If symptoms persist or worsen, seek medical attention promptly,” says Shah. It’s important to pay attention to warning signs, as if heat stroke develops, this is a medical emergency. Shah stresses: “Heat stroke is a severe and potentially life-threatening condition that requires immediate medical intervention. It occurs when the body’s temperature regulation fails, and the core temperature rises dangerously high. “Symptoms may include a high body temperature (above 39.4°C), altered mental state, confusion, rapid breathing, rapid heartbeat, and even loss of consciousness. If you suspect heat stroke, call emergency services immediately.” Sleep deprivation The extra tiredness could also be linked to poor sleep, as this can really suffer in the heat. “Hot temperatures can disrupt sleep and lead to poor sleep quality. The body needs to cool down to initiate sleep, and excessive heat can make it difficult to reach the optimal sleep temperature,” explains Shah. “To improve sleep in hot weather, consider using fans or air conditioning, wearing lightweight and breathable sleepwear, keeping your bedroom well-ventilated, and using lighter bedding.” Pre-existing conditions could get worse Many people living with chronic or long-term health conditions deal with fatigue – which may flare up during heatwaves. “Hot weather can exacerbate symptoms and increase fatigue in individuals with certain chronic health conditions. Conditions such as heart disease, kidney problems, and respiratory issues can be particularly sensitive to heat,” notes Shah. “It’s vital to be aware of your specific health condition and consult with your healthcare provider for personalised advice on managing your symptoms during hot weather. They may recommend staying in cooler environments, adjusting medications, or monitoring your fluid intake more closely.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live 8 tips for surviving Glastonbury with kids David Beckham designs new car collection with Maserati The dos and don’ts of looking after your garden in a heatwave

So you’re planning to go to Glastonbury, but childcare is expensive and you’re wondering if it could be fun to do it as a family. This isn’t something to take lightly however, so what do you need to know before setting off to the festival, kids in tow? First and foremost, children’s tickets are free if kids are aged 12 and under, and there are two family camping fields at Worthy Farm – so bringing them along is feasible if you already have your adult tickets sorted. But, with weather, camping and crowds of the general public to contend with, there is a lot to consider. Here are some parents who’ve done it, and their tips for making it amazing… 1. Sort buggies and bikes Eden Simpson lives near Glastonbury and is excited to head back with her three children this year – who are 12, six and two. In her extensive experience, how you transport kids around the festival is the most important thing. “One of my favourite festivals was 2017 when my now six-year-old was four months old – he was as content as could be in his carrier and I have such fond memories,” says Simpson. “Obviously this is dependent on age, but a decent baby or toddler carrier is great for keeping little ones safe, close and comfortable. If you’d instead prefer to take a buggy, then make sure it’s suitable for off-roading, with decent wheels. Mountain buggies or bicycle trailers are the go-to and we’ve taken the same converted bicycle trailer for several years now. “Add an air horn to ensure people know to move out of the way. Throw in some blankets and fairy lights and voilà, the perfect cosy haven for kids to travel and chill as they get sleepy of an evening by the Pyramid Stage.” 2. Protect their ears Children’s ears are very sensitive and it’s important to protect their hearing from festival noise. “Ear defenders are a must for obvious reasons, so don’t forget to pack them,” says Simpson. 3. Prepare for rain or shine “Be prepared for all weather – the sun can be just as bad as the rain, so bring waterproofs, rain covers, sunscreen and sun shades,” says Simpson of the unpredictable British weather. “I find a couple of cheap shower curtains can be super-handy to use as an extra layer when keeping dry and clean if you’re sitting on the floor, or for covering bags from the rain and dirt.” 4. Tire the kids out early on “Head up to the Kidzfield first thing in the morning and wear the kids out before the music starts in the afternoon, then hopefully you’ll stand a chance of watching what you want, whilst they have a snooze or play with something they’ve crafted there earlier in the day,” says Simpson. 5. Head to the family-friendly camping fields “Opt for family camping. We would make sure we set up shop in Cockmill Meadow or near the Wicket Ground for family-friendly camping,” Simpson says. “We also found Kidney Mead to be a nice family-friendly spot. Even though it’s not a specific family field, it’s centrally located and has easy access to the Pyramid Stage and the Kidzfield. Plus as it’s up the hill, it doesn’t flood,” she explains. When it comes to ensuring youngsters get enough sleep, Martin Wells, 47, dad to 11-year-old Poppy, says: “If they will use an eye mask or ear plugs, use them.” 6. Pack easy-to-spot bright clothes Simpson says: “Make sure your kids are dressed vibrantly and stand out. Not only because it’s Glastonbury Festival so it’s a must, but also because it makes it easier to spot them if they try and wander off.” 7. Don’t over-plan Ashley Thorne, who has been to the iconic festival 15 times – including with his two-year-old, Evan, says: “We decided not to plan to see any bands, we just went with the flow and allowed our little one to decide when he wanted to eat and sleep – it just stopped the stress of having to be at a certain stage at a certain time,” he explains. “Don’t get bogged down with times and eating or sleeping patterns – he was just coming up to two years old, so sitting down and watching the thousands of people walk past him was a game in itself.” 8. Be aware of adult themes Drinking, drugs, nudity and all manner of other not-so-PG things go on at a festival, and you may be worried about your kids encountering some of that. “They’re going to see or smell something,” says Wells. “Try and avoid the obvious areas – Arcadia and the Dance Village [now called Silver Hayes] – but people could be doing balloons at any point, so be aware.” And if they do happen to catch glimpse of something, what’s Wells advice? “I’d just say don’t make a big thing about it. Sure, it’s going to happen and you’re going to see it, but don’t make a big deal out of it. I’m not saying you need to normalise it, but the worse thing you can do is try and hide from it – that won’t happen.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live David Beckham designs new car collection with Maserati The dos and don’ts of looking after your garden in a heatwave Why are we all sleeping so badly at the moment?