So you’ve been counting down to your holiday – when you’ll finally have the chance to step off the hamster wheel and relax. Except, no sooner have you checked in at your hotel than you find yourself reaching for the headache pills or tissues, as a niggling cold or migraine takes hold. Sound familiar? If it feels like you suddenly get unwell when you finally hit the pause button, you’re not imagining it – there’s even a medical term for it. The ‘let-down effect’ “This is known as the ‘let-down effect’,” says Dr Suhail Hussain, a personal physician and private home visiting GP. “When the body is used to functioning on high levels of [stress hormones] cortisol and adrenaline and they suddenly decrease, our immune system is exposed and then we’re prone to minor infections and excessive tiredness. “Pain and muscle aches also increase – adrenaline increases muscle tension, so imagine a rubber band always pulled tight, what happens when you let go? “There may also be a spike in mental health problems, such as acute anxiety and panic attacks. Flare-ups in pre-existing chronic conditions is also a common phenomenon, for example migraine and asthma attacks,” he adds. The ‘let-down effect’ can strike after a brief period of intense stress, such as after exams or completing a project, and after positive high-stress events, like planning a wedding. And for many people, it hits when you finally get to put down your to-do list and go on holiday. What’s the deal with stress hormones? Stress hormones serve an important purpose and we need them to function, so they’re not always bad news. “Basically, we are programmed to respond to danger – ‘fight or flight’ – so in stressful situations, there is an increase in levels of stress hormones adrenaline and cortisol,” Dr Hussain explains. “Together, these two hormones control mood, motivation and fear. In periods of stress or heightened anxiety, adrenaline levels rise – causing an overdrive of the sympathetic nervous system, resulting in racing pulse, high blood pressure, sweating, etc.” Stress hormones also play a role in regulating inflammation, metabolising nutrients, and aiding immune function, sleep and energy. But ideally, they wouldn’t stay at raised levels for too long. “If these hormones are always ‘on’, then inflammatory processes are accelerated and your immune system is impaired,” says Dr Hussain. “Consistently high levels of cortisol in your blood can lead to inflammation and a weakened immune system.” Can you avoid the ‘let-down effect’? Dr Hussain says: “You can try to lessen the impact of the ‘let-down effect’ by de-stressing slowly. Instead of crashing and burning, try to maintain a bit of activity on the holiday or some degree of exercise, such that there’s not a massive decrease in stress hormone levels, meaning you can allow the body to acclimatise slowly.” But not getting sick on holiday may not be the only concern here. If your body is giving you warning signs that chronic stress is taking a toll, it’s important to listen. “Constantly running on high levels of stress is very bad for you. It leads to the problems mentioned above but also longer-term consequences, such as plaque formation in arteries, leading to coronary events and strokes, depression and anxiety, and even addiction. Levels of obesity are also increased,” explains Dr Hussain. He says indications to look out for could include: “Recurrent illnesses, feeling tired, lack of energy. Poor response to glucose, leading to type 2 diabetes, elevated blood pressure and disruption of the sleep-wake cycle.” If you have any concerns, check in with your GP. And Dr Hussain suggests finding ways to make managing stress in everyday life. “Build in regular relaxation to your daily schedule. Get out to walk, spend time in the sun, observe nature. Listen to relaxing music. Make a regular sleep schedule, read, spend time with family and loved ones,” he says. “Don’t just work and work and work for the expectation of a big holiday at the end of it.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live As Katie Boulter takes Wimbledon by storm, we look at her best on-court fashion so far Lioness Katie Zelem: Nerves are good – it’s just about channelling them the right way Church of England should scrap fees of up to £641 for weddings, vicar says

Andrew Ridgeley has had interest from several movie studios about making a Wham! biopic.

Furious competition for Eras Tour seats will fulfil or crush fans' Wildest Dreams.

(This story was originally published Sept. 29. On Thursday, the US Food and Drug Administration granted full approval

Hulk Hogan has spoken candidly about the lifestyle changes he made after his body “shut down” on him, with the former wrestler revealing that he’s given up alcohol completely and lost 40 pounds. The WWE Hall of Famer, 69, opened up about implementing healthier habits during a “Gym & Fridge” video for Men’s Health, where he reflected on his former routines and the impact they ultimately had on his body. In the clip, Hogan, whose real name is Terry Gene Bollea, revealed that his “pre-match meal” used to consist of “three Miller Lites and two Tylenols,” while his post-match meal consisted of “probably 12 Miller Lites”. However, according to Hogan, he decided to give up alcohol entirely six months ago, after he realised he had been using it as a way to “numb” himself. “I don’t drink alcohol at all. I just don’t drink, don’t take Tylenols. I don’t do anything except drink really good water,” Hogan said, before noting that he gave up alcohol “completely” six months ago. “I just got tired of it. It got to be a way to kind of numb me a little bit because I had a bunch of crazy business problems and personal stuff going on at the time.” Hogan also revealed that he chose to stop drinking after realising that he was “getting too aggressive” with alcohol. “I caught myself after I would train, getting too aggressive with alcohol. So I just had to stop it,” he explained. The former professional wrestler, who lost 40 pounds over the last two years, also credited an experience 15 years ago for his decision to change his lifestyle, as Hogan recalled how his body had “shut down” on him after 40 years of wrestling. “About 15 years ago my body kinda shut down on me. I had several knee surgeries … and then after wrestling 40 years almost, my body shut down on me,” he told the outlet. “I went in for one back surgery and it turned into 10 back surgeries. Both knees needed to be replaced. Both hips were replaced. A couple surgeries on my face from getting my orbital socket broken a couple times. “And it ended up being 25 or 26 surgeries, or a couple more, over a 10- or 12-year period.” According to Hogan, the experience “changed the game” for him and encouraged him to change his “whole lifestyle”. “I changed my whole lifestyle because, at the time, being in so much pain and getting older and older, I couldn’t carry that much weight,” he said. “And when you’re sedentary and you’re not moving and wrestling every night, it’s easy to put weight on.” The world renowned wrestling star said he ultimately decided to strive for a weight of 265 pounds, an amount he’d last weighed when he was in “ninth grade”. To reach his goal, and to overhaul his lifestyle, Hogan changed his eating habits, with the 69 year old revealing that he has a cup of yoghurt, a banana and organic coffee for breakfast each morning, while his lunch usually consists of proteins such as chicken, steak or raw tuna. The same is true for Hogan’s dinners, as the wrestler revealed dinner “usually consists of either steak or chicken or tuna”. “It’s pretty much the same,” he admitted, before adding that he also likes to indulge in “organic cookies”. According to Hogan, he also began omitting sugar from his diet after realising it was causing inflammation in his joints. “Sugar had to be eliminated immediately,” he recalled, as he explained that making his body “healthy” became much more important to him than making it “numb”. As for how he feels now, Hogan said he feels “great” and “alive”. “I feel great. Without all the other extra stuff, you actually feel alive, because a little bit of pain makes you know you are alive,” he said. This is not the first time Hogan has opened up about the lifestyle changes he’s made since retiring from wrestling in 2012. In May 2023, the Hogan Knows Best star told Men’s Health that he decided to stop taking pain medicine and drinking alcohol after becoming “sick of the brain fog, the trouble sleeping, feeling tired all the time, and not being myself”. According to Hogan, he was able to get “consistent” with his training “as soon as [he] cut back on the alcohol and straightened out [his] diet”. At the time, Hogan also expressed his gratitude for the lifestyle changes, which he said benefitted him both mentally and physically, as he admitted he “didn’t think this kind of transformation was possible at this stage” in his life. “My whole lifestyle has changed,” he said. Read More Hulk Hogan baffles fans with ‘bizarre’ divorce announcement, says ‘I thought everyone already knew’ Jennifer Lopez defends alcohol brand amid criticism: ‘I drink to be social’ How to go sober if your partner still drinks Father issues warning about mermaid tail swimsuits after daughter almost drowns Daniel Radcliffe says seeing Erin Darke become a mother is ‘most incredible thing’ Fiona Phillips target of telephone scam following Alzheimer’s diagnosis

Eisai Co.’s Alzheimer’s drug Leqembi gained full approval from US regulators, a move expected to widen access to

As tributes pour in, many are focusing on the wider mental health issues facing China.

Out of all the members of the Wu-Tang Clan, RZA may win the award for having the most diverse career.

NEW ORLEANS--(BUSINESS WIRE)--Jul 6, 2023--

U.S. officials have granted full approval to a closely watched Alzheimer’s drug for patients with early stages of the disease

Canada is bracing for higher-than-normal wildfire activity to continue into August, as soaring temperatures and drought turn much

SEATTLE--(BUSINESS WIRE)--Jul 6, 2023--