By Jennifer Rigby LONDON (Reuters) -Obesity drugs will not be included in the World Health Organization's (WHO) latest essential medicines

The warming waters threaten marine life and ocean ecosystems including by bleaching coral reefs.

A grandmother who was diagnosed with a rare cancerous tumour after her ankle “looked a bit swollen” had to have her leg amputated, but she is now walking with a prosthetic and has achieved her goal of waltzing again with her husband. Shirley Parnell, 75, a retired production coordinator, who lives in Kings Langley, Hertfordshire, with her husband, Lawrence, 76, a retired chartered surveyor, noticed a lump on her ankle in July 2022, and little did she know, it would lead to a devastating diagnosis. Shirley “assumed it would be something that (doctors) could fix”, but, after several scans, she was diagnosed with spindle cell sarcoma, a rare malignant cancerous tumour, and was told a leg amputation would be the only way forward. The mum of two and grandmother of two felt “shocked and in disbelief” as it “hadn’t even crossed (her) mind” that she was going to be diagnosed with cancer. After the surgery, Shirley had an “overwhelming sense of relief” and focused on getting better – to motivate herself, she set herself the goal of being able to dance with her husband again. But, while learning to walk again, Shirley was diagnosed with metastasis lung cancer and could not help but feel “a little bit cheated” as her parents lived until their 90s and she now knows “that’s probably not going to happen.” She did not let this get in the way of her achieving her goal, and in the middle June 2023, she danced with her husband again at a friend’s wedding and said she “had a real sense of achievement”. In July 2022, Shirley got her first warning sign of cancer when she experienced pain in her right ankle. Shirley told PA Real Life: “My ankle started to look a bit swollen – at first, I didn’t think anything of it as I assumed I had just knocked it on something in the house and not realised, but then I noticed a lump. “The lump kept moving around and the pain started to get more intense. So much so that I decided to go and see my local GP.” Shirley’s GP thought it could be a blood clot, so she was prescribed cream and tablets, but after a week, nothing improved. She was then referred to Watford General Hospital for a blood test and an X-ray. Shirley said: “I had just assumed it would be something that they could fix with some medication and the thought of something more serious didn’t really cross my mind. “It was only when they said that the X-ray had come back showing some abnormalities and they wanted me to have an MRI scan, a CT scan and a biopsy that I started to worry. “A few weeks went by, and I tried not to think about the results but then I got a call saying the results were back and they wanted to see me, and I just felt like it was going to be bad news.” At the appointment, Shirley was told she had spindle cell sarcoma, a rare malignant cancerous tumour which can develop in the bone or soft tissue. The doctor suggested that the only option for Shirley was to have her leg amputated to remove the tumour. She said: “As he said those words, I felt shocked and disbelief. “I thought at the time, only last week I was living my life normally, doing things I would come to take for granted such as walking to the shops or going to a Pilates class. “It hadn’t even crossed my mind that it might be cancer, let alone that I would lose a limb because of it.” So, on October 24 2022, at the Royal National Orthopaedic Hospital in Stanmore, Greater London, Shirley had the surgery. She said: “I was very nervous going into surgery but funnily enough I was okay once it was done. “I just had an overwhelming sense of relief that that part was finished. “Everyone has always said to me that I am a very determined person and after the surgery, I just started to look to the future as I felt everything was getting better, so I focused on working towards that.” But, once her leg was amputated, Shirley could not help but feel like she had lost some independence. She said: “Before I could just pop out to pick up some essentials but I had to rely on others to help me, something I am learning to get better at. “I’m so grateful for my husband running me around though.” On January 27 2023, Shirley had a cast made for her prosthetic leg, and it was fitted a week later. She said: “Then came the long and challenging journey of learning how to walk again. “The staff at the Prosthetic Rehabilitation Unit at the Royal National Orthopaedic Hospital were amazing and their support was what got me through those first few weeks and helped me get used to my new way of moving. “I felt strange but excited with my new leg – it felt like it was a real step forward into being more independent.” When in physiotherapy, Shirley made it her goal to be able to dance at her friend’s wedding with her husband. She said: “My husband and I always loved dancing – he joked that we’ll be doing a jive, but I said maybe a slow waltz.” But, at the end of April 2023, she was diagnosed with lung cancer. She said: “My parents lived until they were well into their 90s and I’ll be honest, I fully accepted with my family history that I would do the same. “So it came as a bit of a shock that I now know that that’s probably not going to happen. “I felt a little bit cheated, I suppose, but the other thing it has made me realise is that there are people a lot worse off than me.” Determined not to let the diagnosis impact her goal, Shirley practised walking even more, and at the middle June 2023, they danced together at the wedding. She said: “It was wonderful, I had a real sense of achievement, and being able to have a few dances during the evening was wonderful. “My husband was really proud of me too. “My family have been unbelievably supportive, I can’t thank them enough. “They were so happy for me that day.” Now, Shirley remains under the hospital’s care, having regular scans, and has since passed her driving assistance test. She is also raising money for the Royal National Orthopaedic Hospital Charity for its Impossible Possible campaign. Looking back on the last few years, she said: “I appreciate things a lot more now – I take time to appreciate my garden, the flowers blossoming, and my family. “I feel so lucky that I could have the amputation, and it puts things into perspective definitely.” Read More Mother reveals bruise on her toddler’s eye led to cancer diagnosis Jonnie Irwin details experience with palliative hospice care Ben Cohen’s ex-wife says she had only ‘one symptom’ before cancer diagnosis What is cardiac arrest? The condition that LeBron James’ son suffered from Mom left ‘appalled’ after water park says she can’t breastfeed son in lazy river Government has more work to do to ensure families secure quality childcare – MPs

Zachary Levi is uncertain about his future in the DC Extended Universe (DCEU) after the poor box office performance of 'Shazam! Fury of the Gods'.

When the greenhouse gases released from Canada’s 2023 wildfires are eventually tallied, they will be at least double

A study has found the best exercises to lower blood pressure, so get ready to go to the gym. Research published in the British Journal of Sports Medicine and conducted at Canterbury Christ Church and Leicester universities, compared the efficacy of different forms of exercise on reducing blood pressure and found that “isometric exercises” – which involve engaging muscles without moveme are your best bet. That means it is time to hold a wall-sit, or plank for ages. Fun times. The study examined 270 randomised controlled clinical trials, involving 15,827 participants, on the effects of different types of exercise on resting blood pressure. It even found that these isometric techniques were almost twice as effective as government recommended exercises, aerobic activity like cycling and walking, though they found these other forms of exercise were effective too. Reducing blood pressure reduces your chance of stroke, heart failure, and other issues. Sign up to our free Indy100 weekly newsletter Over-40s are advised to have it checked every five years. Treatment often involves medication but patients are also advised to eat healthily, reduce alcohol intake, stop smoking and exercise regularly. Jamie O’Driscoll, a reader in cardiovascular physiology at Canterbury Christ Church university and senior author of the report, said in isometric exercises the muscle remained contracted but did not change in length. This static contraction could squeeze the vessels that supplied blood to the working muscles – which reduced the flow of blood to the muscle during the exercise and therefore oxygen supply to the muscle. When the muscle relaxed afterwards, it caused a large flow of blood through the vessels (this was different to other modes of exercise) and was likely to be the trigger driving these greater improvements in blood flow regulation. “Performing 4 x 2 minutes of wall sits, with 2-minutes’ rest in between, three times per week, is an effective way to reduce your blood pressure,” said O’Driscoll. “They should be done alongside other exercise modes, to provide the maximum range of exercise choices rather than limiting them.” Dr Kush Joshi, a sports and exercise medicine consultant and fellow of the Faculty of Sport and Exercise Medicine, welcomed the study’s findings, but questioned how easy it would be for patients to do. “The reality is a significant proportion of the population will not be able to do a plank or wall sits, and furthermore may not enjoy these types of activities,” he said. “Solutions need to be found to make these exercises accessible to all individuals with elevated blood pressure, and the study should provide impetus to policymakers to make exercise the bedrock of treatment of not only high blood pressure but other medical conditions and so to reduce the burden of medication for the population.” Joanne Whitmore, a senior cardiac nurse at the British Heart Foundation, said it was encouraging to see the benefits of other forms of exercise, as well as aerobic exercise. “We know that those who take on exercise they enjoy tend to carry on for longer, which is key in maintaining lower blood pressure.” But she said it was important to make lifestyle changes too, such as losing weight, eating more healthily and reducing alcohol consumption. Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

As temperatures hit 119F in Phoenix last Thursday, doctors at Valleywise Health Medical Center saw a patient whose

Blur don't think they've played a better gig than their recent Wembley Stadium shows.

Designer Christian Cowan had a full circle moment when he recently dressed pop legend Kylie Minogue. “There are two moments when I decided I wanted to be in fashion, and they’re both around Kylie Minogue,” Cowan remembers. “One was in Borders bookshop in Cambridge [where Cowan grew up], my mum was getting a coffee and I was waiting – on the TV was the Can’t Get You Out Of My Head music video. I was like, ‘What is that? That is what I need to do’. “Then for my 12th birthday, my mum was really sweet and got me tickets to see Kylie’s X tour in the O2. It was right in the nosebleed seats at the back, and I was living my best life.” Cowan designed a red jumpsuit with zips for Minogue to perform in New York, and says: “To dress people like that, people who I really looked up to and still look up to is always an honour.” And Minogue isn’t the only celebrity who has worn Cowan’s colourful, whimsical designs. Pretty much any star you can think of, Cowan will have dressed – Lady Gaga, Sam Smith, Lizzo, Lil Nas X, Heidi Klum, Cardi B, Miley Cyrus – the list goes on. While pop stars definitely seem to gravitate to his work, Cowan says there’s no real limit to who wears his clothes. “The Christian Cowan person is anyone, but it’s someone who wants to enjoy themselves, it’s someone who wants to be complimented and get attention. It’s someone who enjoys the fun of dressing up – our customers in general, they’re not really dressing for the gaze or perspective of anyone else – they’re just feeling f****** fabulous.” Cowan went to university in London and now resides in New York – and he says he gets inspiration from both major fashion hubs. The US “leans more into maximalism, and [is] not afraid of opulence and showing off, which is very much part of my brand”, he reflects. “And the UK I’d say is more [about] pushing the boundaries and trying out new things.” Ultimately, both cities are “incredibly fashionable and stylish and have created original thinkers – so I feel very lucky to be between the two”. Cowan established his eponymous label in 2016 so feels like an industry stalwart by now, but he’s still only 29 years old. “I started my brand and career very young,” he admits. “I would definitely say it’s grown up with me – the collections that I put out at the beginning are by no means the collections I’m putting out now.” But he doesn’t feel embarrassed when looking back at earlier work, instead calling his collections “like a diary”. “You can see as I grew up, the big life experiences that happened influenced [my style]. To say it has matured – maybe that’s the wrong word – but I would say my references have gotten more expansive with time. I look further than I used to – before it was like, who was next to me in the club.” While he doesn’t go to the clubs as much as he used to (“I’m like an old man!”), he occasionally pops in (“I love to see what my friends are wearing”), while getting inspiration from elsewhere as well. “I’m definitely a child of the internet, the internet is a huge part of it. I think designing is almost like dreaming – it’s a random compilation of everything you’ve seen, all smudged into one thing.” Cowan has made a name for himself as someone who loves to collaborate, and he often gets inspiration from his creative partners – ranging from the Teletubbies to Crocs, and now, Candy Crush Saga, who he’s designed an exclusive garment for. Called ‘The Sweet Seat’, it’s a one-of-a-kind, wearable garment inspired by the dreaded task of finding a seat to play on public transport. “Collaboration is the key to success in general in life – work, personal, everything,” he muses. “So when doing these collaborations, whether it’s a dress for Lady Gaga or this Candy Crush partnership, it’s always super collaborative. I want their opinion, I want their input, I want both partners involved and to be excited. “Especially with a celebrity wearing the clothes as well, you want them to feel amazing and excited to wear the piece – you don’t bully them into wearing something they’re not fully down for. You always have a better result if you collaborate.” Working with Candy Crush gave Cowan a welcome pause from designing his next New York Fashion Week collection, set to debut in September. “We’re doing a few things we’ve never done before that I think will be surprising to people – I just can’t wait. It’s our biggest show, the collection’s over double the size of any collection we’ve ever done before,” he shares. With designing collections for fashion week twice a year, making bespoke outfits for celebrities and all the extra projects in between, does Cowan ever suffer from fashion burnout? Cowan admits to having “brief moments in my past” where he’s struggled, but adds: “When you feel that it means you need to try something new, and I never had it again after I realised that. “I make sure I’m filled with creative, fun projects – I don’t think I’d ever get burnt out. I want to be doing this until the day I die.” The limited-edition Sweat Seat will be available for purchase on christiancowan.com/candycrush for £786.92 from July 26. Download Candy Crush today on Google Play or the App Store. Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Deborah James’s daughter launches anniversary clothing line for Bowelbabe Fund Government has more work to do to ensure families secure quality childcare – MPs Wall squat exercises can help lower blood pressure, study suggests

‘Beer tanning’ is one of the latest beauty fads to trend on TikTok, with the ‘beertan’ tag racking up over 200k views. As the phrase suggests, beer tanning means applying beer to the skin while sunbathing, in the belief it will enhance the tanning process. Some fans of the method on social media have been applying beer as well as SPF, while others have skipped sun-care altogether and simply rubbed beer onto their skin. What is ‘beer tanning’ and is it safe? “The beer tanning trend involves using beer as an alternative to traditional tanning lotions to achieve a sun-kissed glow. Proponents of this trend claim that the sugars and acids in beer can help darken the skin, and potentially provide additional benefits due to the presence of antioxidants and vitamins in some beer types,” Caroline Brooks, skin specialist and founder of The Glasshouse Salon & Spa, told PA Media. “However, it’s important to note that there is no scientific evidence to support the effectiveness or safety of using beer for tanning purposes.” Serious health risks Dr Maham Khan, consultant dermatologist at the Cadogan Clinic, stressed it’s “crucial to approach this trend with caution” as there are potentially serious sun safety concerns. “As a consultant dermatologist treating patients with skin cancer on a daily basis, I feel compelled to stress the utmost importance of exercising caution and mindfulness when it comes to the TikTok trend of ‘beer tanning’. While the desire to achieve a glowing tan is understandable, it is crucial to approach this trend with caution and prioritise sun protection,” said Khan. “Applying beer to the skin in the belief that it enhances tanning is a questionable practice that lacks scientific evidence. More importantly, this method does not provide any protection against the harmful effects of ultraviolet (UV) radiation from the sun. “UV radiation is a known carcinogen and a major contributor to skin damage, which can manifest as sunburn, premature ageing, and an increased risk of skin cancer, including melanoma.” Protecting your skin in the sun is vital SPF is important for all skin types and skin tones. While it’s especially vital for people with naturally pale complexions, even those who don’t think they have a tendency to burn need to protect themselves in the sun. “I cannot stress enough the significance of using quality and appropriate SPF products to shield the skin from harmful UV rays,” Dr Khan added. “Sunscreen with a high SPF rating, along with broad-spectrum protection, is essential to safeguard the skin effectively. “However, it’s crucial to note that sunscreen alone may not offer complete protection, and additional measures such as seeking shade, wearing protective clothing and avoiding sun exposure during peak hours, are equally vital. “Furthermore, it is imperative to understand that a tan is not a sign of healthy skin, but rather an indication of damage. Even if individuals manage to achieve a tan through unconventional methods like beer tanning, it should not be considered a safe or desirable practice.” Is it ever worth trying a beer tan? According to the experts – no. If you do enjoy a beer at the beach, stick to drinking it (preferably under a nice shady umbrella). “The safest and most effective way to achieve a sun-kissed glow is by using self-tanning products or spray tans, that are specifically formulated for this purpose and have undergone rigorous testing to ensure their safety and effectiveness,” said Brooks. “Always prioritise the health and wellbeing of your skin when considering any beauty or tanning trend.” Dr Khan added: “I strongly advise against engaging in the beer tanning trend or any other unproven and potentially harmful methods of tanning. Instead, let’s be responsible and informed about the risks associated with sun exposure, diligently using SPF protection and taking steps to safeguard our skin. “By prioritising sun safety, we can enjoy the outdoors responsibly, while minimising the risk of skin damage and potential health consequences.” Read More Charity boss speaks out over ‘traumatic’ encounter with royal aide Ukraine war’s heaviest fight rages in east - follow live Christian Cowan: Designing is like dreaming Deborah James’s daughter launches anniversary clothing line for Bowelbabe Fund Government has more work to do to ensure families secure quality childcare – MPs

Fire-ravaged Greece is the focus of Mediterranean heat, with temperatures set to climb back up to 47C (116.6F)

The Princess of Wales has been labelled a “disappointment’ with regards to her approach to jewellery. Former Vogue editor and fashion critic Suzy Menkes made the remarks during an interview on the newest episode of her podcast Creative Conversations. Speaking to British Vogue’s jewellery editor Carol Woolton, the two discussed and analysed some of Kate Middleton’s recent style choices, explaining to listeners that as a senior member of the royal family, she would surely have access to some of the finest jewels in the country. “The Princess of Wales is a bit of a disappointment about jewellery,” said Menkes. “She gives the impression that she only puts it on when she absolutely has to.” The 79-year-old critic continued: “I imagine her looking beautiful in one of those gowns behind the scenes and then pulling a face as if to say, ‘Do I have to wear this?’ “She doesn’t give any sense of adoring jewellery and being pleased to put it on.” Menkes went on to suggest that Queen Camilla seems far more interested in jewellery, stating: “[Kate] doesn’t seem to have Camilla’s joy at wearing jewellery.” She went on: “We now have a new Queen, so presumably she has a first opportunity to look at the jewels. “We can imagine that the next in line to the throne’s wife would be something that was very special, so will we see Catherine wearing jewellery that is more dramatic, that is more personal to her? I don’t know. I can’t help feeling with things of beauty, you either love it or you don’t.” Later in the podcast, Menkes went on to discuss some of the controversy that the royal family’s jewellery collection has garnered over the years. “It’s one of these strange secrets,” she said. “It’s not discussed, and I can see why because some of the pieces are dubious. They came from India. “I won’t say they were stolen but they were perhaps given and taken by the British Royal Family. They weren’t stealing it but they were taking over a country at that time, and and taking jewels they thought were an attractive thing to take back to England with them.” Read More Kate Middleton’s sweet tradition for Prince George’s birthday Kate Middleton and Princess Charlotte wear matching ruffles for eight-year-old’s first Wimbledon Adorable moment young boy meets Kate Middleton at Wimbledon Fans defend Prince Harry and Meghan Markle amid breakup rumours Kate Middleton’s sweet tradition for Prince George’s birthday Kate Middleton and Princess Charlotte wear matching ruffles for Wimbledon finals