A planned multibillion-euro hydrogen link between Spain and France is set to qualify for European Union aid as

Carrie Fisher's final movie, "Wonderwell," shows the late actress playing a good witch alongside Rita Ora.

Business is booming at Boston University, which is borrowing $224 million in the municipal bond market next week.

Impact Your World has gathered ways you can help reject the pathology of racism and celebrate Juneteenth more thoughtfully through nonprofits that support Black health and wealth, joy, and overall empowerment.

Meta Platforms said on Friday a policy that was put in place to curb the spread of misinformation

One of the scientists whose work pioneered the development of medications such as Ozempic and Wegovy has revealed why life may become “so miserably boring” after two years of using the drug. Ozempic is an FDA-approved medication used for the treatment of type 2 diabetes. It works by mimicking a hormone called glucagon-like peptide 1 (GLP-1), which regulates blood sugar levels and slows down the rate at which food leaves the stomach, often creating the feeling of fullness. These semaglutide injections – sold under the brand names Ozempic and Wegovy – have soared in popularity as many people, including Hollywood celebrities, have used it for weight loss. What’s more, people have also found Ozempic has been effective in curing their addictive habits, like drinking, smoking, shopping, or nail biting. However, because of Ozempic’s increasing popularity, it has led to national shortages of the type 2 diabetes treatment – leaving those who actually need it without. In an interview with Wired, professor Jens Juul Holst – who received the Warren Alpert Foundation Prize in 2021 for his work developing treatments based on the GLP-1 hormone – spoke about the effects of Ozempic, and why he believes many people will stop taking the medication after just a few years. “What happens is that you lose your appetite and also the pleasure of eating, and so I think there’s a price to be paid when you do that,” Holst told Wired. “If you like food, then that pleasure is gone. The craving for food for some people is taken away when they take GLP-1 drugs.” He continued: “That may eventually be a problem, that once you’ve been on this for a year or two, life is so miserably boring that you can’t stand it any longer and you have to go back to your old life.” Holst added that medications like Ozempic and Wegovy have been on the market since 2005, though studies show that these people don’t stay on them for very long. “It’s just like every other drug, they don’t stay on it for many reasons,” he explained. “One of the reasons, as I said, is that once you have tried it and you realise you’ve lost interest in food, then that may be enough.” “We don’t know why people stop taking these drugs, but we know for a fact that they do stop. They do that all over the world.” A 2020 study found that 70 per cent of people who took GLP-1 drugs for type 2 diabetes stopped taking them within two years. However, this could pose a problem for many patients taking semaglutide injections. Research has found that people who stopped taking Ozempic or Wegovy for weight loss experienced weight rebound. A trial published in April 2022 saw participants gain back two thirds of the weight they had lost after 68 weeks of taking semaglutide. As for celebrities who use the once-weekly injection for weight loss, despite not having diabetes or clinical obesity, Hans instead called attention to the “many terrible problems” that those with diabetes have struggled with by not having drugs like Ozempic readily available. “Have you ever visited a diabetes hospital? It’s really deplorable,” he said. “People come in with amputated limbs and compromised cognitive functions and heart problems or they can barely move – they’re miserable and depressed. It’s really serious. There is so much you can improve with a drug that is not only a weight-loss drug but is also an anti-diabetic.” Amidst the popularity of semaglutide injections, the US Food and Drug Administration has issued warnings for consumers not to use off-brand versions of Ozempic or Wegovy, because they may not include the same GLP-1 hormone used in approved medications. Earlier this month, agency officials reported problems with patients using compounded versions of semaglutide – which combines traditional semaglutide with other ingredients. These drugs are not FDA-approved, and the agency does not verify the safety or effectiveness of compounded drugs. Consumers should only use drugs containing semaglutide with a prescription from a licensed health care provider and obtained from a state-licensed pharmacy or other facilities registered with the FDA, the agency said. Read More What is ‘Ozempic face’? Doctors warn about facial ageing side effect of diabetes medications How does Wegovy work? The ‘game changing’ weight loss drug beloved by Hollywood FDA warns against using off-brand versions of Ozempic, Wegovy for weight loss Pregnant Stassi Schroeder admits she wants to ‘try’ Ozempic after giving birth Doctors warn about ‘Ozempic face’ side effect of medications Amy Schumer says she stopped taking Ozempic because of side-effects

The tough, stuck-on messes on your baking sheets require aggressive cleaning products.

The promotional line for "The Blackening" is so good -- "We can't all die first" -- there was reason to fear the movie couldn't live up to it. Yet like other self-referential horror/comedies (the "Scream" franchise come to mind), the film ably delivers on its premise, mining enough life from its satirical concept to deliver plenty of crowd-pleasing moments.

It’s not often that a single scientific discovery manages to change the way we think about the entire history of humanity. An ancient footprint has been newly uncovered, and it turns out that humans were walking around 30,000 years earlier than we previously thought. Two-legged homo sapiens were living in South Africa, it’s been proven, following the discovery of a 153,000 year old track. It was found in the Garden Route National Park near the coastal town of Knysna on the Cape South Coast. Sign up to our free Indy100 weekly newsletter The footmarks outdate the oldest previous discoveries, with the previous oldest found in nearby areas dated at 124,000 years old. The discoveries were made possible thanks to the optically-stimulated luminescence dating method, which analyses how long it’s been since a grain of sand has been exposed to sunlight. Researchers Charles Helm of Nelson Mandela University and the University of Leicester's Andrew Carr wrote in the Conversation: "In 2023, the situation is very different. It appears that people were not looking hard enough or were not looking in the right places. "Today, the African tally for dated hominin ichnosites (a term that includes both tracks and other traces) older than 50,000 years stands at 14. "Given that relatively few skeletal hominin remains have been found on the Cape coast, the traces left by our human ancestors as they moved about ancient landscapes are a useful way to complement and enhance our understanding of ancient hominins in Africa." The scientists involved believe that the area could be home to many illuminating discoveries given the makeup of the soil. They wrote: "We suspect that further hominin ichnosites are waiting to be discovered on the Cape South Coast and elsewhere on the coast. "The search also needs to be extended to older deposits in the region, ranging in age from 400,000 years to more than 2 million years. "A decade from now, we expect the list of ancient hominin ichnosites to be a lot longer than it is at present – and that scientists will be able to learn a great deal more about our ancient ancestors and the landscapes they occupied." Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

While Father's Day is an annual tradition celebrated the third Sunday in June, there are several organizations that support dads year-round.

Ever wondered how water first arrived on our planet? Well, it turns out the mystery could finally have been solved. Researchers have undertaken detailed analysis of asteroids and the findings could change the way the scientific community think about origins of water on our planet. Experts at the University of Arizona's Lunar and Planetary Laboratory (LPL) have discovered salt crystals on samples recovered from space. As their findings state, these crystals could only have formed with the presence of water. Sign up to our free Indy100 weekly newsletter The research was undertaken on samples of the asteroid Itokawa in 2005 by the Japanese Hayabusa mission. It suggests that S-type asteroids could be home to more water than previously thought. The new findings led some scientists to claim that water is likely to have arrived on asteroids when our planet was first being formed. The senior’s author Tom Zega said: "The grains look exactly like what you would see if you took table salt at home and placed it under an electron microscope. "They're these nice, square crystals. It was funny, too, because we had many spirited group meeting conversations about them, because it was just so unreal. Zega added: "It has long been thought that ordinary chondrites are an unlikely source of water on Earth. Our discovery of sodium chloride tells us this asteroid population could harbour much more water than we thought." Itokawa is a S-type asteroid, and it’s thought that temperatures on their surfaces were too high for water to form. Shaofan Che, who is the lead study author, said: "In other words, the water here on Earth had to be delivered from the outer reaches of the solar nebula, where temperatures were much colder and allowed water to exist, most likely in the form of ice. "The most likely scenario is that comets or another type of asteroid known as C-type asteroids, which resided farther out in the solar nebula, migrated inward and delivered their watery cargo by impacting the young Earth." Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

Does very hot weather leave you feeling more exhausted and lethargic than usual? There might be an initial surge of joy when the sun finally comes out – but once temperatures really creep up, we can end up feeling physically drained, wondering whether we should follow the Mediterranean’s lead and start introducing daily siestas. So, why does hot weather make us so tired? We asked a doctor to explain… Our bodies have to work harder in the heat “When the weather is hot, our bodies have to work harder to cool themselves down,” says Dr Zulqarnain Shah, medical director at SSP Health and GP at SSP Health practice Colne Road Surgery. “The body’s natural cooling mechanism involves increasing blood circulation near the skin’s surface and promoting sweat production. These physiological changes can lead to fatigue and a feeling of lethargy. It is essential to recognise that this fatigue is a normal response to heat and is typically temporary.” Dehydration Low energy and tiredness are also common when you’re lacking hydration. “Hot weather increases the rate of fluid loss through sweating, leading to dehydration. Dehydration can contribute to fatigue and make you feel even more lethargic,” adds Dr Shah. “To avoid this, it’s important to stay adequately hydrated by drinking plenty of fluids, especially water. Aim to drink even when you’re not feeling thirsty, as thirst is not always an accurate indicator of dehydration.” Heat exhaustion “Prolonged exposure to heat can result in heat exhaustion, a condition characterised by symptoms such as heavy sweating, weakness, dizziness, nausea, headache, and muscle cramps. If you experience these warning signs, it’s crucial to move to a cooler environment, drink fluids, and rest. If symptoms persist or worsen, seek medical attention promptly,” says Shah. It’s important to pay attention to warning signs, as if heat stroke develops, this is a medical emergency. Shah stresses: “Heat stroke is a severe and potentially life-threatening condition that requires immediate medical intervention. It occurs when the body’s temperature regulation fails, and the core temperature rises dangerously high. “Symptoms may include a high body temperature (above 39.4C), altered mental state, confusion, rapid breathing, rapid heartbeat, and even loss of consciousness. If you suspect heat stroke, call emergency services immediately.” Sleep deprivation The extra tiredness could also be linked to poor sleep, as this can really suffer in the heat. “Hot temperatures can disrupt sleep and lead to poor sleep quality. The body needs to cool down to initiate sleep, and the excessive heat can make it difficult to reach the optimal sleep temperature,” explains Shah. “To improve sleep in hot weather, consider using fans or air conditioning, wearing lightweight and breathable sleepwear, keeping your bedroom well-ventilated, and using lighter bedding.” Pre-existing conditions could get worse Many people living with chronic or long-term health conditions deal with fatigue, which may flare up during heatwaves. “Hot weather can exacerbate symptoms and increase fatigue in individuals with certain chronic health conditions. Conditions such as heart disease, kidney problems, and respiratory issues can be particularly sensitive to heat,” notes Shah. “It’s vital to be aware of your specific health condition and consult with your healthcare provider for personalised advice on managing your symptoms during hot weather. They may recommend staying in cooler environments, adjusting medications, or monitoring your fluid intake more closely.” Read More Airbnb customer furious after being charged extra over dog hair People seek hay fever advice once every three seconds, says NHS England Why is my hay fever so bad at the moment?